A rare urinary JC virus reactivation after long-term therapy with rituximab

The possible role of JC virus in determining urinary tract involvement has only recently been recognized. case a man with laboratory-confirmed replication the urine after maintenance schedule rituximab administered for lymphoproliferative disorder is reported herein. patient developed severe renal and impairment, characterized by onset nephropathy, bilateral ureteral strictures, serious reduction vesical compliance, ultimately requiring an ileal neobladder configuration. was finally attributed to reactivation. This observation suggests that diseases related might be associated long-term treatment.